This is the treatment of choice for male factor infertility in which the sperm count is less than 5 millions/ml, sperm defects, dead, immotile, abnormal sperms, unexplained infertility and failed IVF. ICSI is a micromanipulation procedure whereby a single sperm is injected into the single egg with the help of small micro needle with the help of robotic machine called micromanipulator. Super ovulation, follicular monitoring, ovum pick up is done like that in IVF. This technique may provide men who have very small amounts of weak sperm (too small for routine IVF) a chance to fertilize individual eggs. When the egg is fertilized, the embryo is inserted into the uterus.