Donner egg IVF is a fertility treatment in which the egg from the donor is mixed with the sperm from the biological father in the laboratory. If embryos are produced they are transferred to the recipients uterus. If this results in a pregnancy, the baby thus born will have genetic linkage to the donor of eggs.
Indication
A need for egg donation may arise for a number of reasons. Infertile couple may resort to acquiring eggs through egg donation when the female partner may not have eggs or poor quality eggs because of advanced reproductive age or other reasons.
Compromised egg quantity / quality
Premature ovarian failure (POF), defined as woman less than 40 years old with persistent amenoirlenea & raised genadotropins. it affect 1% of female population. Majority are idiopathic, but about 20% are suspected to be autoimmune in nature.
Chemotherapy & Radiation treatment for cancer.
Compromise or Removal of the ovaries for treatment of malignancies or for non-cancerous conditions like infection, torsion or over aggressive removal of dermoids or endometrioma.
Poor or compromised ovarian reserve because of advanced reproductive age by D 2/3 S.FSH (> 15 MIU/ml), estradiol (>45 pg/ml) or S.inhibin B.
Repeated IVF failures because of poor fertilization rates or poor oocyte quality.
Recurrent pregnancy loss.
Rarely ovaries inaccessible to either trans vaginal or laparoscopic route.
Physiological menopause.
Congenital absence of eggs.
Turner Syndrome (45 X o).
Gonadal dysgenesis.
Inheritable diseases.
Linked or autosomal traits, however preimplantation genetic diagnosis may be useful in these cases.
